The R75 and its rival the KS 750 were both widely used by the Wehrmacht in Russia and North Africa, though after a period of evaluation it became clear that the KS 750 was the superior machine. In August 1942 on the urging of the Army, agreed upon standardization of parts for both machines, with a view of eventually creating a hybrid (designated the BW 43), in which a 286/1 side-car would be grafted onto a KS 750 motorcycle. They also agreed that the manufacture of the R75 would cease once production reached 20,200 units, and after that point would only produce the hybrid machine, manufacturing 20,000 each year.
Since the target of 20,200 R75's was not reached, it remained in production until the Eisenach factory was so badly damaged by Allied bombing that production ceased in 1944.
However the standardisation programme meant that machines that were produced used 70% of the same components. This simplifies the supply of spare parts for these vehicles, many of which are still in the hands of historic motorcycle enthusiasts. These vehicles are still highly desirable as collector's items because of their complex and durable technology, and are correspondingly expensive. A well-restored R75 can be still used for everyday purposes, on or off-road without problems.
In 1954 a small number of modified R75's was produced at Eisenach (then in Soviet-controlled East Germany) for testing under the designation AWO 700, but were not put into full production.